PF3D7_0713700

Genome location: Pf3D7_07_v3:621,090..623,717(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MFKKFFVFITFLVFIIKYIHC

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.03	0.98
Trophozoite	possibly expressed	0.12	0.92
Schizont	expressed	0.07	0.94
Gametocyte	expressed	0.07	0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0713700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.153 | MFS: -3.211 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1420300)

Relative Growth Rate: 0.10 ± nan
Confidence: 1.00

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4M7

"Best" AlphaFill ligand hit: AMP (adenosine monophosphate, Local RMSD=0.82) with 4NNJ (Global RMSD=21.07)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533635

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	5	2	15
disruptive	6	8	6	13
missense	6	8	5	13

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	17	8	20
disruptive	7	34	15	71
missense	7	20	13	46

PlasmoDB Total SNPs: 178

Non-coding: 159 | Synonymous: 12 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 209 | Molecular Weight (kDa): 24.381

UniProt ID(s): C0H4M7

PDB ID(s): None

Isoelectric Point: 5.03

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A