PF3D7_0713800 (NELFA)

Genome location: Pf3D7_07_v3:623,870..625,625(-)

Genome classification: Core

Function and Localization

Product Description: negative elongation factor A, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.98
Trophozoite	not expressed	0.08	0.94
Schizont	expressed	0.44	0.74
Gametocyte	expressed	0.06	0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0713800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.135 | MFS: -3.214 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1420400)

Relative Growth Rate: 0.87 ± 0.06
Confidence: 7.12

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1420400)

Modification: Disrupted | RMgm-3836

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBV9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_138265

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	10	4	5
disruptive	3	9	2	19
missense	3	7	2	17

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	22	8	10
disruptive	7	36	22	60
missense	4	20	15	29

PlasmoDB Total SNPs: 69

Non-coding: 62 | Synonymous: 5 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 240 | Molecular Weight (kDa): 28.383

UniProt ID(s): Q8IBV9

PDB ID(s): None

Isoelectric Point: 8.55

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A