PF3D7_0713900

Genome location: Pf3D7_07_v3:626,391..641,230(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0008080	N-acetyltransferase activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	1.47	0.41
Trophozoite	expressed	1.85	0.22
Schizont	expressed	0.99	0.55
Gametocyte	not expressed	0.87	0.57

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0713900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.479 | #Insertions: 8

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532991

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	54	127	64	148
disruptive	214	615	269	676
missense	125	427	202	497

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	76	243	128	192
disruptive	393	1126	470	1044
missense	212	806	351	646

PlasmoDB Total SNPs: 821

Non-coding: 255 | Synonymous: 294 | Nonsynonymous: 272 | Stop Codon: 0

Protein Information

Protein Length: 3569 | Molecular Weight (kDa): 415.231

UniProt ID(s): C0H4M8

PDB ID(s): None

Isoelectric Point: 4.82

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF141571	N/A