PF3D7_0714100

Genome location: Pf3D7_07_v3:646,719..648,767(-)

Genome classification: Core

Function and Localization

Product Description: MAATS1 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.97
Trophozoite	not expressed	0.03	0.98
Schizont	not expressed	0.04	0.97
Gametocyte	not expressed	0.36	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0714100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.688 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBV6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105032

Most Similar Human Ortholog: H7C5C8

TM-align score: 0.53 | RMSD: 3.49

Seq Identity: 0.06 | Length: 80 / 682

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000183833	cilia and flagella associated protein 91
ENSG00000285585	novel protein

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	13	13	28
disruptive	16	41	33	78
missense	11	33	24	65

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	52	27	30
disruptive	31	113	67	144
missense	15	79	54	84

PlasmoDB Total SNPs: 27

Non-coding: 0 | Synonymous: 16 | Nonsynonymous: 11 | Stop Codon: 0

Protein Information

Protein Length: 682 | Molecular Weight (kDa): 82.044

UniProt ID(s): Q8IBV6

PDB ID(s): None

Isoelectric Point: 8.07

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR026720	Cilia- and flagella-associated protein 91
InterPro	IPR032840	CFAP91 domain
PFam	PF14738	CFAP91 domain
Superfamily	N/A	N/A