About Gene List

PF3D7_0714200

Genome location: Pf3D7_07_v3:650,460..655,136(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.87 0.60
Trophozoite not expressed 0.86 0.54
Schizont possibly expressed 1.17 0.41
Gametocyte not expressed 0.66 0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0714200

Resistome Missense Mutations: K864N, G866C, N870K, C872G

Resistome Compounds with Missense Mutations: Desoxyepothilone B

Resistome # Samples with Disruptive Mutations: 5 (5 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.143 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBV5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532783

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 11 73 27 66
disruptive 64 179 93 227
missense 36 148 85 187

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 21 123 55 79
disruptive 109 363 171 379
missense 61 293 144 249

PlasmoDB Total SNPs: 148

Non-coding: 38 | Synonymous: 60 | Nonsynonymous: 50 | Stop Codon: 0

Protein Information

Protein Length: 1361 | Molecular Weight (kDa): 159.529

UniProt ID(s): Q8IBV5

PDB ID(s): None

Isoelectric Point: 5.58

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108