PF3D7_0714400

Genome location: Pf3D7_07_v3:662,068..664,084(-)

Genome classification: Core

Function and Localization

Product Description: calmodulin, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0005509	calcium ion binding
Process	GO:0007165	signal transduction

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	not expressed	0.15	0.91
Schizont	not expressed	0.02	0.99
Gametocyte	not expressed	0.32	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0714400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.826 | MFS: -2.665 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1421000)

Modification: Mutated | RMgm-5378

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBV3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533645

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	6	3	13
disruptive	6	13	2	28
missense	4	12	2	24

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	9	8	21
disruptive	11	33	27	65
missense	5	25	21	31

PlasmoDB Total SNPs: 73

Non-coding: 62 | Synonymous: 6 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 256 | Molecular Weight (kDa): 30.801

UniProt ID(s): Q8IBV3

PDB ID(s): None

Isoelectric Point: 4.72

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011992	EF-hand domain pair
PFam	N/A	N/A
Superfamily	SSF47473	EF-hand domain pair