Product Description: transcription elongation factor s-II, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Component | GO:0008023 | transcription elongation factor complex |
| Process | GO:0032784 | regulation of DNA-templated transcription, elongation |
| Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.44 | 0.79 |
| Trophozoite | expressed | 0.67 | 0.62 |
| Schizont | expressed | 0.20 | 0.87 |
| Gametocyte | not expressed | 0.39 | 0.77 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0714500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.168 | MFS: -2.857 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1421100)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IBV2
"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=19.35) with 2QTH (Global RMSD=18.30)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101177
Most Similar Human Ortholog: A0A1W2PS15
TM-align score: 0.80 | RMSD: 1.26
Seq Identity: 0.09 | Length: 45 / 403
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000171703 | transcription elongation factor A2 |
| ENSG00000187735 | transcription elongation factor A1 |
| ENSG00000204219 | transcription elongation factor A3 |
| ENSG00000282941 | transcription elongation factor A3 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 1 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 1 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 155
Non-coding: 116 | Synonymous: 22 | Nonsynonymous: 16 | Stop Codon: 1
Protein Length: 403 | Molecular Weight (kDa): 47.352
UniProt ID(s): Q8IBV2
PDB ID(s): None
Isoelectric Point: 8.01
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001222 | Zinc finger, TFIIS-type |
| InterPro | IPR003618 | Transcription elongation factor S-II, central domain |
| InterPro | IPR017923 | Transcription factor IIS, N-terminal |
| InterPro | IPR035100 | Transcription elongation factor, IIS-type |
| InterPro | IPR035441 | TFIIS/LEDGF domain superfamily |
| InterPro | IPR036575 | Transcription elongation factor S-II, central domain superfamily |
| PFam | PF01096 | Zinc finger, TFIIS-type |
| PFam | PF07500 | Transcription elongation factor S-II, central domain |
| PFam | PF08711 | Transcription factor IIS, N-terminal |
| Superfamily | SSF46942 | Transcription elongation factor S-II, central domain superfamily |
| Superfamily | SSF47676 | TFIIS/LEDGF domain superfamily |
| Superfamily | SSF57783 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |