PF3D7_0714600

Genome location: Pf3D7_07_v3:667,505..670,119(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.76	0.66
Trophozoite	expressed	0.88	0.55
Schizont	expressed	0.46	0.73
Gametocyte	expressed	0.48	0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0714600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.31 | MFS: -2.587 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1421200)

Relative Growth Rate: 0.23 ± 0.08
Confidence: 6.48

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1421200)

Modification: Disrupted | RMgm-3842

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBV1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_145931

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	17	10	25
disruptive	29	66	53	120
missense	15	56	48	95

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	39	25	32
disruptive	56	194	83	208
missense	24	153	53	106

PlasmoDB Total SNPs: 203

Non-coding: 123 | Synonymous: 46 | Nonsynonymous: 34 | Stop Codon: 0

Protein Information

Protein Length: 575 | Molecular Weight (kDa): 67.349

UniProt ID(s): Q8IBV1

PDB ID(s): None

Isoelectric Point: 10.41

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A