PF3D7_0715100 (MYCBP)

Genome location: Pf3D7_07_v3:674,505..675,251(-)

Genome classification: Core

Function and Localization

Product Description: C-Myc-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Function	GO:0003713	transcription coactivator activity
Process	GO:0006355	regulation of transcription, DNA-templated

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.01	1.00
Trophozoite	possibly expressed	0.01	0.99
Schizont	possibly expressed	0.09	0.94
Gametocyte	expressed	0.58	0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0715100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.141 | MFS: -3.055 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBU9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103096

Most Similar Human Ortholog: Q99417

TM-align score: 0.56 | RMSD: 2.96

Seq Identity: 0.21 | Length: 71 / 108

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000214114	MYC binding protein

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	rare	doubleton	singleton
synonymous	5	7	5
disruptive	13	7	17
missense	13	7	17

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	14	6	9
disruptive	1	27	15	30
missense	1	26	14	24

PlasmoDB Total SNPs: 66

Non-coding: 62 | Synonymous: 1 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 108 | Molecular Weight (kDa): 12.792

UniProt ID(s): Q8IBU9

PDB ID(s): None

Isoelectric Point: 4.32

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR026060	Associate of Myc 1
PFam	N/A	N/A
Superfamily	N/A	N/A