PF3D7_0715200

Genome location: Pf3D7_07_v3:675,522..682,899(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MSHNPASILLFTVQGLLA

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.12	0.94
Trophozoite	expressed	0.91	0.55
Schizont	expressed	1.13	0.47
Gametocyte	expressed	1.90	0.25

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0715200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.289 | #Insertions: 8

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1421500)

Modification: Disrupted | RMgm-3843

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBU8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533588

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	18	90	36	111
disruptive	120	273	150	319
missense	69	191	122	253

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	35	156	73	124
disruptive	182	582	265	558
missense	101	429	208	332

PlasmoDB Total SNPs: 471

Non-coding: 74 | Synonymous: 195 | Nonsynonymous: 201 | Stop Codon: 1

Protein Information

Protein Length: 2206 | Molecular Weight (kDa): 258.401

UniProt ID(s): Q8IBU8

PDB ID(s): None

Isoelectric Point: 6.47

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A