PF3D7_0715400 (PSOP20)

Genome location: Pf3D7_07_v3:687,618..689,135(-)

Genome classification: Core

Function and Localization

Product Description: secreted ookinete protein, putative

SignalP Peptide: MNKMNKIICLMLYVSLINLTQS

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	expressed	0.10	0.94
Schizont	expressed	0.04	0.97
Gametocyte	expressed	0.63	0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0715400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.83 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1421700)

Modification: Disrupted | RMgm-3845

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZXA3

"Best" AlphaFill ligand hit: NDP (nadph dihydro-nicotinamide-adenine-dinucleotide phosphate, Local RMSD=0.62) with 6LH9 (Global RMSD=21.11)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533276

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	13	5	12
disruptive	3	12	6	23
missense	1	11	6	20

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	25	9	13
disruptive	6	35	26	51
missense	3	22	23	40

PlasmoDB Total SNPs: 86

Non-coding: 75 | Synonymous: 9 | Nonsynonymous: 1 | Stop Codon: 1

Protein Information

Protein Length: 219 | Molecular Weight (kDa): 25.691

UniProt ID(s): A0A143ZXA3

PDB ID(s): None

Isoelectric Point: 8.38

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A