Product Description: ATP synthase subunit epsilon, mitochondrial, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.6.3.14 (Transferred entry: 7.1.2.2)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005743 | mitochondrial inner membrane |
| Component | GO:0005753 | mitochondrial proton-transporting ATP synthase complex |
| Component | GO:0005756 | mitochondrial proton-transporting ATP synthase, central stalk |
| Component | GO:0005739 | mitochondrion |
| Process | GO:0015986 | ATP synthesis coupled proton transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.01 | 1.00 |
| Trophozoite | expressed | 0.09 | 0.95 |
| Schizont | expressed | 0.01 | 0.99 |
| Gametocyte | expressed | 0.22 | 0.87 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0715500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 1 | MFS: -1.82 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IBU5
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.6.3.14 | H+-transporting two-sector ATPase | No BRENDA inhibitors |
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P05632 | ATP synthase subunit beta,/delta,/epsilon,/gamma, mitochondrial | Bos taurus | OrthoMCL | CHEMBL7871CHEMBL269080CHEMBL416142CHEMBL8116... |
Ortholog Group (OrthoMCL): OG6_103560
Most Similar Human Ortholog: P56381
TM-align score: 0.77 | RMSD: 1.40
Seq Identity: 0.27 | Length: 48 / 71
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000124172 | ATP synthase F1 subunit epsilon |
Protein Length: 71 | Molecular Weight (kDa): 8.496
UniProt ID(s): Q8IBU5
PDB ID(s): None
Isoelectric Point: 8.81
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006721 | ATP synthase, F1 complex, epsilon subunit, mitochondrial |
| InterPro | IPR036742 | ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial |
| PFam | PF04627 | ATP synthase, F1 complex, epsilon subunit, mitochondrial |
| Superfamily | SSF48690 | ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 1 | 0 | 1 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 96
Non-coding: 93 | Synonymous: 3 | Nonsynonymous: 0 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 21984828 | ATP synthase complex of Plasmodium falciparum: dimeric assembly in mitochondrialmembranes and resistance to genetic disruption. | Nina PB, Morrisey JM, ..., Vaidya AB | 10.1074/jbc.M111.290973 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |