Product Description: GTP-binding translation elongation factor tu family protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Component | GO:1990904 | ribonucleoprotein complex |
| Function | GO:0005525 | GTP binding |
| Function | GO:0003924 | GTPase activity |
| Function | GO:0003746 | translation elongation factor activity |
| Process | GO:0006414 | translational elongation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.04 | 0.98 |
| Trophozoite | expressed | 0.36 | 0.78 |
| Schizont | expressed | 0.10 | 0.93 |
| Gametocyte | expressed | 0.23 | 0.86 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0715600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.121 | MFS: -2.943 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1421900)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IBU4
"Best" AlphaFill ligand hit: DXC ((3alpha,5beta,12alpha)-3,12-dihydroxycholan-24-oic acid, Local RMSD=0.11) with 4AC9 (Global RMSD=6.06)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 26 | 16 | 42 |
| disruptive | 3 | 34 | 17 | 60 |
| missense | 3 | 33 | 17 | 51 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 57 | 21 | 38 |
| disruptive | 10 | 85 | 50 | 128 |
| missense | 5 | 74 | 43 | 93 |
PlasmoDB Total SNPs: 109
Non-coding: 80 | Synonymous: 20 | Nonsynonymous: 9 | Stop Codon: 0
Protein Length: 754 | Molecular Weight (kDa): 86.237
UniProt ID(s): Q8IBU4
PDB ID(s): None
Isoelectric Point: 8.79
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000640 | Elongation factor EFG, domain V-like |
| InterPro | IPR000795 | Transcription factor, GTP-binding domain |
| InterPro | IPR005225 | Small GTP-binding protein domain |
| InterPro | IPR006298 | GTP-binding protein TypA |
| InterPro | IPR009000 | Translation protein, beta-barrel domain superfamily |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| InterPro | IPR035647 | EF-G domain III/V-like |
| InterPro | IPR035651 | BipA, domain V |
| PFam | PF00009 | Transcription factor, GTP-binding domain |
| PFam | PF00679 | Elongation factor EFG, domain V-like |
| Superfamily | SSF50447 | Translation protein, beta-barrel domain superfamily |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| Superfamily | SSF54980 | EF-G domain III/V-like |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |