PF3D7_0715700

Genome location: Pf3D7_07_v3:694,095..695,200(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.00	1.00
Trophozoite	expressed	0.04	0.97
Schizont	expressed	0.01	0.99
Gametocyte	expressed	0.06	0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0715700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.161 | MFS: -3.047 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBU3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_146173

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	2	4	10
disruptive	2	1	1	6
missense	2	1	1	6

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	7	10	3
disruptive	2	6	7	21
missense	2	6	6	15

PlasmoDB Total SNPs: 74

Non-coding: 72 | Synonymous: 2 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 119 | Molecular Weight (kDa): 14.417

UniProt ID(s): Q8IBU3

PDB ID(s): None

Isoelectric Point: 10.25

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A