PF3D7_0715800 (DMT1)

Genome location: Pf3D7_07_v3:695,091..697,180(-)

Genome classification: Core

Function and Localization

Product Description: drug/metabolite transporter DMT1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 9

EC Numbers: 3.6.3.44 (Transferred entry: 7.6.2.2)

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016021	integral component of membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.10	0.95
Trophozoite	expressed	0.72	0.60
Schizont	expressed	0.14	0.91
Gametocyte	expressed	0.67	0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0715800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.847 | MFS: -3.052 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1422100)

Relative Growth Rate: 0.89 ± 0.14
Confidence: 5.32

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PbANKA_1422100)

Modification: Disrupted | RMgm-4340

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBU2

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC #	Name	EC Inhibitors
3.6.3.44	xenobiotic-transporting ATPase	BRENDA SOAP query unsuccessful

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_110001

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	27	8	23
disruptive	15	41	19	57
missense	13	38	17	48

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	56	14	27
disruptive	25	84	38	112
missense	21	70	25	75

PlasmoDB Total SNPs: 146

Non-coding: 111 | Synonymous: 17 | Nonsynonymous: 16 | Stop Codon: 2

Protein Information

Protein Length: 434 | Molecular Weight (kDa): 50.249

UniProt ID(s): Q8IBU2

PDB ID(s): None

Isoelectric Point: 9.09

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000620	EamA domain
PFam	PF00892	EamA domain
Superfamily	SSF103481	N/A