Product Description: cation diffusion facilitator family protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 6
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
| Component | GO:0005887 | integral component of plasma membrane |
| Component | GO:0005886 | plasma membrane |
| Function | GO:0005385 | zinc ion transmembrane transporter activity |
| Process | GO:0071577 | zinc ion transmembrane transport |
| Process | GO:0006829 | zinc ion transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | possibly expressed | 0.06 | 0.97 |
| Trophozoite | expressed | 0.56 | 0.68 |
| Schizont | expressed | 0.21 | 0.87 |
| Gametocyte | expressed | 0.27 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0715900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.312 | #Insertions: 2
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1422200)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_1424200)
Modification: Disrupted | RMgm-4788
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IBU1
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100508
Most Similar Human Ortholog: Q8IWU4
TM-align score: 0.81 | RMSD: 2.08
Seq Identity: 0.33 | Length: 315 / 556
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000104154 | solute carrier family 30 member 4 |
| ENSG00000115194 | solute carrier family 30 member 3 |
| ENSG00000158014 | solute carrier family 30 member 2 |
| ENSG00000164756 | solute carrier family 30 member 8 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 26 | 17 | 37 |
| disruptive | 9 | 46 | 18 | 69 |
| missense | 7 | 40 | 17 | 64 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 15 | 49 | 24 | 41 |
| disruptive | 16 | 106 | 59 | 132 |
| missense | 11 | 93 | 44 | 88 |
PlasmoDB Total SNPs: 191
Non-coding: 160 | Synonymous: 18 | Nonsynonymous: 13 | Stop Codon: 0
Protein Length: 556 | Molecular Weight (kDa): 62.944
PDB ID(s): None
Isoelectric Point: 6.26
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002524 | Cation efflux protein |
| InterPro | IPR027469 | Cation efflux transmembrane domain superfamily |
| InterPro | IPR036837 | Cation efflux protein, cytoplasmic domain superfamily |
| PFam | PF01545 | Cation efflux protein |
| Superfamily | SSF160240 | Cation efflux protein, cytoplasmic domain superfamily |
| Superfamily | SSF161111 | Cation efflux transmembrane domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 31118298 | The Vacuolar Zinc Transporter Tg ZnT Protects Toxoplasma gondii from Zinc Toxicity | Chasen NM, Stasic AJ, ..., Moreno SNJ | 10.1128/mSphere.00086-19 |
| 35404116 | PMRT1, a Plasmodium-Specific Parasite Plasma Membrane Transporter, Is Essentialfor Asexual and Sexual Blood Stage Development. | Wichers JS, Mesen-Ramirez P, ..., Strauss J | 10.1128/mbio.00623-22 |