PF3D7_0716000

Genome location: Pf3D7_07_v3:702,601..706,721(+)

Genome classification: Core

Function and Localization

Product Description: RNA-binding protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0071004	U2-type prespliceosome
Component	GO:0089701	U2AF complex
Component	GO:0000243	commitment complex
Component	GO:0016607	nuclear speck
Function	GO:0008187	poly-pyrimidine tract binding
Function	GO:0030628	pre-mRNA 3'-splice site binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.87	0.62
Trophozoite	expressed	1.20	0.41
Schizont	expressed	0.23	0.86
Gametocyte	expressed	1.19	0.41

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0716000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.255 | MFS: -2.619 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBU0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_122481

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	15	68	28	81
disruptive	83	202	85	200
missense	31	108	62	130

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	26	130	44	69
disruptive	144	347	145	358
missense	61	202	98	181

PlasmoDB Total SNPs: 255

Non-coding: 74 | Synonymous: 90 | Nonsynonymous: 91 | Stop Codon: 0

Protein Information

Protein Length: 1125 | Molecular Weight (kDa): 132.716

UniProt ID(s): Q8IBU0

PDB ID(s): None

Isoelectric Point: 9.17

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000504	RNA recognition motif domain
InterPro	IPR035979	RNA-binding domain superfamily
PFam	N/A	N/A
Superfamily	SSF54928	RNA-binding domain superfamily