About Gene List

PF3D7_0716100 (SDA1)

Genome location: Pf3D7_07_v3:706,991..711,199(-)

Genome classification: Core

Function and Localization

Product Description: protein SDA1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005730 nucleolus
Process GO:0042273 ribosomal large subunit biogenesis
Process GO:0000055 ribosomal large subunit export from nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 1.46 0.42
Trophozoite expressed 0.90 0.55
Schizont expressed 0.27 0.86
Gametocyte expressed 0.77 0.59

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0716100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.19 | MFS: -3.271 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0613800)

  • Relative Growth Rate: 0.17 ± 0.20
  • Confidence: 4.56

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBT9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102265

Most Similar Human Ortholog: F8W8T7

TM-align score: 0.79 | RMSD: 1.13

Seq Identity: 0.19 | Length: 62 / 1069

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000198301 SDA1 domain containing 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 44 24 54
disruptive 44 146 67 166
missense 18 93 55 125

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 13 85 36 64
disruptive 91 280 109 231
missense 30 176 88 170

PlasmoDB Total SNPs: 284

Non-coding: 133 | Synonymous: 72 | Nonsynonymous: 79 | Stop Codon: 0

Protein Information

Protein Length: 1069 | Molecular Weight (kDa): 126.477

UniProt ID(s): Q8IBT9

PDB ID(s): None

Isoelectric Point: 6.53

Protein Domain Annotations:

Source Family ID Description
InterPro IPR016024 Armadillo-type fold
InterPro IPR027312 Sda1
PFam N/A N/A
Superfamily SSF48371 Armadillo-type fold

Associated Publications

PMID Title Authors DOI/Link
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
30624622 Transcriptome profile with 20 nm silver nanoparticles in yeast Horstmann C, Campbell C, Kim DS, Kim K 10.1093/femsyr/foz003
27390266 The N-terminal extension of yeast ribosomal protein L8 is involved in two majorremodeling events during late nuclear stages of 60S ribosomal subunit assembly Tutuncuoglu B, Jakovljevic J, ..., Woolford JL Jr 10.1261/rna.055798.115
31731522 Transcriptome Profile Alteration with Cadmium Selenide/Zinc Sulfide Quantum Dotsin Saccharomyces cerevisiae Horstmann C, Kim DS, Campbell C, Kim K 10.3390/biom9110653