PF3D7_0716200

Genome location: Pf3D7_07_v3:711,820..715,046(+)

Genome classification: Core

Function and Localization

Product Description: PDCD2 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	1.57	0.39
Trophozoite	expressed	1.34	0.50
Schizont	expressed	0.58	0.73
Gametocyte	expressed	0.74	0.60

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0716200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.153 | MFS: -2.763 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0613900)

Relative Growth Rate: 0.03 ± 0.05
Confidence: 7.37

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBT8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103745

Most Similar Human Ortholog: F5GWT2

TM-align score: 0.74 | RMSD: 2.63

Seq Identity: 0.36 | Length: 87 / 832

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000071994	programmed cell death 2

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	40	17	39
disruptive	82	91	56	124
missense	30	64	47	103

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	79	29	56
disruptive	110	199	103	256
missense	43	159	80	143

PlasmoDB Total SNPs: 274

Non-coding: 144 | Synonymous: 71 | Nonsynonymous: 58 | Stop Codon: 1

Protein Information

Protein Length: 832 | Molecular Weight (kDa): 96.7

UniProt ID(s): Q8IBT8

PDB ID(s): None

Isoelectric Point: 4.75

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR007320	Programmed cell death protein 2, C-terminal
PFam	PF04194	Programmed cell death protein 2, C-terminal
Superfamily	N/A	N/A