PF3D7_0716300

Genome location: Pf3D7_07_v3:716,275..719,340(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: MKVWGACFFVALLAGLIKKKVEC

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.40	0.82
Trophozoite	expressed	2.33	0.14
Schizont	expressed	0.88	0.62
Gametocyte	expressed	0.75	0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0716300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.574 | MFS: -2.253 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0614000)

Relative Growth Rate: 0.09 ± 0.09
Confidence: 6.28

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0614000)

Modification: Tagged | RMgm-4526

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBT7

"Best" AlphaFill ligand hit: AN2 (amp phosphoramidate, Local RMSD=15.65) with 3IED (Global RMSD=16.42)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532326

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	8	13	26
disruptive	20	30	25	46
missense	15	22	21	37

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	32	27	37
disruptive	27	71	49	146
missense	17	50	36	94

PlasmoDB Total SNPs: 178

Non-coding: 100 | Synonymous: 37 | Nonsynonymous: 41 | Stop Codon: 0

Protein Information

Protein Length: 522 | Molecular Weight (kDa): 60.601

UniProt ID(s): Q8IBT7

PDB ID(s): None

Isoelectric Point: 4.14

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
30379851	Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation.	Briquet S, Ourimi A, ..., Vaquero C	10.1371/journal.pone.0205596