PF3D7_0716400

Genome location: Pf3D7_07_v3:719,353..721,623(+)

Genome classification: Core

Function and Localization

Product Description: transcription initiation factor IIA subunit 1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.09	0.96
Trophozoite	expressed	0.36	0.77
Schizont	expressed	0.17	0.88
Gametocyte	expressed	0.44	0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0716400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.14 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0614100)

Relative Growth Rate: 0.02 ± 0.03
Confidence: 8.28

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZY73

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532917

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	5	5	5
disruptive	3	7	4	16
missense	0	4	4	15

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	13	4	16
disruptive	6	37	13	34
missense	0	28	12	28

PlasmoDB Total SNPs: 120

Non-coding: 116 | Synonymous: 4 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 174 | Molecular Weight (kDa): 20.01

UniProt ID(s): A0A143ZY73

PDB ID(s): None

Isoelectric Point: 4.33

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR009088	Transcription factor IIA, beta-barrel
PFam	N/A	N/A
Superfamily	SSF50784	Transcription factor IIA, beta-barrel