PF3D7_0716500

Genome location: Pf3D7_07_v3:721,717..725,068(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0031304	intrinsic component of mitochondrial inner membrane
Component	GO:0005739	mitochondrion
Function	GO:0016491	oxidoreductase activity
Function	GO:0004729	oxygen-dependent protoporphyrinogen oxidase activity
Process	GO:0006783	heme biosynthetic process

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.06	0.97
Trophozoite	expressed	0.34	0.80
Schizont	expressed	0.09	0.94
Gametocyte	expressed	0.31	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0716500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.653 | MFS: -3.058 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4M9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532946

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	17	17	24
disruptive	7	36	33	57
missense	7	34	32	50

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	34	26	24
disruptive	17	96	51	99
missense	13	81	42	79

PlasmoDB Total SNPs: 353

Non-coding: 327 | Synonymous: 17 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 446 | Molecular Weight (kDa): 52.897

UniProt ID(s): C0H4M9

PDB ID(s): None

Isoelectric Point: 10.34

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A