PF3D7_0716700

Genome location: Pf3D7_07_v3:728,081..731,148(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.10	0.95
Trophozoite	expressed	0.32	0.80
Schizont	expressed	0.15	0.90
Gametocyte	expressed	0.53	0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0716700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.206 | MFS: -2.764 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0614400)

Relative Growth Rate: 0.09 ± 0.11
Confidence: 5.82

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBT3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532744

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	54	24	50
disruptive	63	128	57	139
missense	53	119	51	133

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	23	76	29	68
disruptive	103	232	88	175
missense	83	198	75	135

PlasmoDB Total SNPs: 169

Non-coding: 17 | Synonymous: 64 | Nonsynonymous: 86 | Stop Codon: 2

Protein Information

Protein Length: 1005 | Molecular Weight (kDa): 121.611

UniProt ID(s): Q8IBT3

PDB ID(s): None

Isoelectric Point: 9.52

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A