Product Description: eukaryotic translation initiation factor 3 subunit I, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005852 | eukaryotic translation initiation factor 3 complex |
| Component | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003743 | translation initiation factor activity |
| Process | GO:0002183 | cytoplasmic translational initiation |
| Process | GO:0006446 | regulation of translational initiation |
| Process | GO:0006413 | translational initiation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.51 | 0.75 |
| Trophozoite | expressed | 0.87 | 0.54 |
| Schizont | expressed | 0.10 | 0.94 |
| Gametocyte | expressed | 0.53 | 0.69 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0716800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.143 | MFS: -2.97 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0614500)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IBT2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q14761 | Protein tyrosine phosphatase receptor type C-associated protein | Homo sapiens | OrthoDB | CHEMBL227622CHEMBL376571CHEMBL325416 |
Ortholog Group (OrthoMCL): OG6_101932
Most Similar Human Ortholog: Q13347
TM-align score: 0.93 | RMSD: 1.65
Seq Identity: 0.33 | Length: 315 / 327
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000084623 | eukaryotic translation initiation factor 3 subunit I |
Protein Length: 327 | Molecular Weight (kDa): 37.284
UniProt ID(s): Q8IBT2
PDB ID(s): None
Isoelectric Point: 6.9
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001680 | WD40 repeat |
| InterPro | IPR011047 | Quinoprotein alcohol dehydrogenase-like superfamily |
| InterPro | IPR019775 | WD40 repeat, conserved site |
| InterPro | IPR024977 | Anaphase-promoting complex subunit 4, WD40 domain |
| InterPro | IPR027525 | Eukaryotic translation initiation factor 3 subunit I |
| PFam | PF00400 | WD40 repeat |
| PFam | PF12894 | Anaphase-promoting complex subunit 4, WD40 domain |
| Superfamily | SSF50998 | Quinoprotein alcohol dehydrogenase-like superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 15 | 8 | 14 |
| disruptive | 2 | 4 | 1 | 14 |
| missense | 1 | 4 | 1 | 11 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 26 | 11 | 16 |
| disruptive | 3 | 11 | 12 | 39 |
| missense | 1 | 8 | 7 | 32 |
PlasmoDB Total SNPs: 176
Non-coding: 166 | Synonymous: 10 | Nonsynonymous: 0 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 37216290 | Plasmodium falciparum Eukaryotic Translation Initiation Factor 3 is Stabilized byQuinazoline-Quinoline Bisubstrate Inhibitors | Dobrescu I, Hammam E, ..., Nardella F | 10.1021/acsinfecdis.3c00127 |