About Gene List

PF3D7_0716900 (DMT2)

Genome location: Pf3D7_07_v3:734,609..737,460(+)

Genome classification: Core

Function and Localization

Product Description: drug/metabolite transporter DMT2

SignalP Peptide: N/A

# Transmembrane Domains: 9

EC Numbers: 3.6.3.44 (Transferred entry: 7.6.2.2)

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast
Component GO:0016020 membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.04 0.98
Trophozoite expressed 0.17 0.89
Schizont expressed 0.04 0.98
Gametocyte expressed 0.25 0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0716900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.122 | MFS: -3.195 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0614600)

  • Relative Growth Rate: 0.13 ± 0.12
  • Confidence: 5.68

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0614600)

Modification: Tagged | RMgm-1409

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBT1

"Best" AlphaFill ligand hit: No AlphaFill hits

BRENDA EC Inhibitors:

EC # Name EC Inhibitors
3.6.3.44 xenobiotic-transporting ATPase BRENDA SOAP query unsuccessful

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_111177

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 8 17 8 21
disruptive 0 3 3 9
missense 0 3 1 6

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 10 35 12 16
disruptive 7 12 16 41
missense 2 4 12 26

PlasmoDB Total SNPs: 148

Non-coding: 131 | Synonymous: 15 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 322 | Molecular Weight (kDa): 37.276

UniProt ID(s): Q8IBT1

PDB ID(s): None

Isoelectric Point: 9.63

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily SSF103481 N/A

Associated Publications

PMID Title Authors DOI/Link
26796412 Functional profiles of orphan membrane transporters in the life cycle of themalaria parasite. Kenthirapalan S, Waters AP, Matuschewski K, Kooij TW 10.1038/ncomms10519
28902970 A genetic screen in rodent malaria parasites identifies five new apicoplastputative membrane transporters, one of which is essential in human malariaparasites Sayers CP, Mollard V, ..., Goodman CD 10.1111/cmi.12789
35404116 PMRT1, a Plasmodium-Specific Parasite Plasma Membrane Transporter, Is Essentialfor Asexual and Sexual Blood Stage Development. Wichers JS, Mesen-Ramirez P, ..., Strauss J 10.1128/mbio.00623-22