PF3D7_0717000

Genome location: Pf3D7_07_v3:737,988..741,576(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 8

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0016020	membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	possibly expressed	0.16	0.89
Schizont	possibly expressed	0.21	0.86
Gametocyte	possibly expressed	0.21	0.87

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0717000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.703 | MFS: -2.707 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_0617400)

Modification: Disrupted | RMgm-4761

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZVX7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215336

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	12	8	21
disruptive	4	9	10	23
missense	4	9	10	21

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	27	10	16
disruptive	7	31	19	50
missense	6	18	16	34

PlasmoDB Total SNPs: 298

Non-coding: 286 | Synonymous: 9 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 298 | Molecular Weight (kDa): 35.939

UniProt ID(s): A0A143ZVX7

PDB ID(s): None

Isoelectric Point: 7.12

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A