PF3D7_0717100

Genome location: Pf3D7_07_v3:741,609..744,981(+)

Genome classification: Core

Function and Localization

Product Description: CRAL/TRIO domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.10	0.95
Trophozoite	expressed	0.70	0.61
Schizont	expressed	0.32	0.80
Gametocyte	expressed	0.34	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0717100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.88 | #Insertions: 7

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4N1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105245

Most Similar Human Ortholog: Q9NXN4

TM-align score: 0.46 | RMSD: 3.67

Seq Identity: 0.21 | Length: 258 / 912

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000196505	ganglioside induced differentiation associated protein 2

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	15	50	16	47
disruptive	60	102	60	130
missense	31	63	39	89

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	31	65	23	63
disruptive	85	185	86	180
missense	46	102	64	112

PlasmoDB Total SNPs: 200

Non-coding: 74 | Synonymous: 72 | Nonsynonymous: 54 | Stop Codon: 0

Protein Information

Protein Length: 912 | Molecular Weight (kDa): 108.934

UniProt ID(s): C0H4N1

PDB ID(s): None

Isoelectric Point: 6.88

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001251	CRAL-TRIO lipid binding domain
InterPro	IPR002589	Macro domain
InterPro	IPR036865	CRAL-TRIO lipid binding domain superfamily
InterPro	IPR043472	Macro domain-like
PFam	PF01661	Macro domain
Superfamily	SSF52087	CRAL-TRIO lipid binding domain superfamily
Superfamily	SSF52949	Macro domain-like