PF3D7_0717200

Genome location: Pf3D7_07_v3:745,040..747,459(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.30	0.85
Trophozoite	expressed	0.48	0.72
Schizont	expressed	1.06	0.43
Gametocyte	expressed	0.61	0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0717200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.5 | MFS: -2.423 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0614900)

Relative Growth Rate: 0.80 ± 0.13
Confidence: 5.54

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0614900)

Modification: Disrupted | RMgm-2122

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4N2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_132688

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	8	18	3	20
disruptive	9	35	9	42
missense	8	25	8	36

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	28	7	17
disruptive	19	66	28	67
missense	10	46	19	43

PlasmoDB Total SNPs: 253

Non-coding: 184 | Synonymous: 40 | Nonsynonymous: 29 | Stop Codon: 0

Protein Information

Protein Length: 431 | Molecular Weight (kDa): 50.262

UniProt ID(s): C0H4N2

PDB ID(s): None

Isoelectric Point: 7.04

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A