PF3D7_0717800

Genome location: Pf3D7_07_v3:767,357..771,949(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.05	0.97
Trophozoite	expressed	0.22	0.88
Schizont	expressed	0.14	0.92
Gametocyte	expressed	0.33	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0717800

Resistome Missense Mutations: M483K

Resistome Compounds with Missense Mutations: MMV665882

Resistome # Samples with Disruptive Mutations: 3 (3 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.389 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBS2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533147

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	56	34	73
disruptive	103	183	95	277
missense	41	126	75	203

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	12	109	46	82
disruptive	165	388	177	384
missense	57	274	137	270

PlasmoDB Total SNPs: 222

Non-coding: 0 | Synonymous: 115 | Nonsynonymous: 107 | Stop Codon: 0

Protein Information

Protein Length: 1530 | Molecular Weight (kDa): 181.788

UniProt ID(s): Q8IBS2

PDB ID(s): None

Isoelectric Point: 9.87

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A