PF3D7_0717900

Genome location: Pf3D7_07_v3:772,279..775,568(-)

Genome classification: Core

Function and Localization

Product Description: thioredoxin-like protein

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.29	0.87
Trophozoite	expressed	0.88	0.56
Schizont	expressed	0.11	0.94
Gametocyte	expressed	0.89	0.54

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0717900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.14 | MFS: -2.871 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0615600)

Relative Growth Rate: 0.07 ± 0.08
Confidence: 6.45

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBS1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139506

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	17	3	25
disruptive	7	16	16	51
missense	3	10	13	45

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	24	13	26
disruptive	17	53	30	93
missense	5	38	24	78

PlasmoDB Total SNPs: 232

Non-coding: 197 | Synonymous: 33 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 449 | Molecular Weight (kDa): 53.378

UniProt ID(s): Q8IBS1

PDB ID(s): None

Isoelectric Point: 8.75

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR013766	Thioredoxin domain
InterPro	IPR036249	Thioredoxin-like superfamily
PFam	PF00085	Thioredoxin domain
Superfamily	SSF52833	Thioredoxin-like superfamily