PF3D7_0718000

Genome location: Pf3D7_07_v3:776,141..795,637(-)

Genome classification: Core

Function and Localization

Product Description: dynein heavy chain, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0030286	dynein complex
Function	GO:0045505	dynein intermediate chain binding
Function	GO:0051959	dynein light intermediate chain binding
Function	GO:0008569	minus-end-directed microtubule motor activity
Process	GO:0007018	microtubule-based movement

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.08	0.96
Trophozoite	not expressed	0.14	0.93
Schizont	not expressed	0.10	0.95
Gametocyte	not expressed	1.44	0.45

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0718000

Resistome Missense Mutations: R29K, G1913D, N1916D, G1917D, K1919E, K1919N, D1925N, D1929N

Resistome Compounds with Missense Mutations: AN13762, AN13956, Cipargamin/KAE609/NITD609, MMV024101, Proguanil

Resistome # Samples with Disruptive Mutations: 21 (18 missense, 1 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.669 | #Insertions: 38

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0615700)

Modification: Disrupted | RMgm-2129

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532757

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	33	163	113	261
disruptive	232	457	229	616
missense	114	284	170	450

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	56	354	172	310
disruptive	391	893	409	917
missense	160	571	299	633

PlasmoDB Total SNPs: 929

Non-coding: 259 | Synonymous: 351 | Nonsynonymous: 312 | Stop Codon: 7

Protein Information

Protein Length: 5846 | Molecular Weight (kDa): 698.87

UniProt ID(s): C0H4N5

PDB ID(s): None

Isoelectric Point: 8.71

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR004273	Dynein heavy chain region D6 P-loop domain
InterPro	IPR013602	Dynein heavy chain, domain-2
InterPro	IPR026983	Dynein heavy chain
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
InterPro	IPR035699	Dynein heavy chain, hydrolytic ATP-binding dynein motor region
InterPro	IPR041228	Dynein heavy chain, C-terminal domain
InterPro	IPR041466	Dynein heavy chain, AAA 5 extension domain
InterPro	IPR041658	Dynein heavy chain AAA lid domain
PFam	PF03028	Dynein heavy chain region D6 P-loop domain
PFam	PF08393	Dynein heavy chain, domain-2
PFam	PF12774	Dynein heavy chain, hydrolytic ATP-binding dynein motor region
PFam	PF12775	Dynein heavy chain, AAA 5 extension domain
PFam	PF17852	Dynein heavy chain AAA lid domain
PFam	PF18198	Dynein heavy chain, C-terminal domain
PFam	PF18199
Superfamily	SSF52540	P-loop containing nucleoside triphosphate hydrolase