Product Description: cysteine repeat modular protein 2
SignalP Peptide: MRNSDFFFFFFVLLNCFLNIQPYVSNA
# Transmembrane Domains: 10
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0031362 | anchored component of external side of plasma membrane |
| Component | GO:0009897 | external side of plasma membrane |
| Process | GO:0030522 | intracellular receptor signaling pathway |
| Process | GO:0046907 | intracellular transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | not expressed | 0.01 | 0.99 |
| Schizont | not expressed | 0.10 | 0.94 |
| Gametocyte | not expressed | 0.03 | 0.98 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0718300
Resistome Missense Mutations: G1633E
Resistome Compounds with Missense Mutations: Suloctidil
Resistome # Samples with Disruptive Mutations: 2 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.19 | #Insertions: 29
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0615900)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0615900)
Modification: Disrupted | RMgm-2131
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IBR8
"Best" AlphaFill ligand hit: 3JD (2-{4-[(3s)-piperidin-3-yl]phenyl}-2h-indazole-7-carboxamide, Local RMSD=0.76) with 7KK5 (Global RMSD=23.08)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 77 | 46 | 96 |
| disruptive | 17 | 88 | 47 | 141 |
| missense | 17 | 79 | 45 | 124 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 26 | 153 | 62 | 98 |
| disruptive | 40 | 175 | 79 | 238 |
| missense | 26 | 134 | 73 | 199 |
PlasmoDB Total SNPs: 161
Non-coding: 63 | Synonymous: 72 | Nonsynonymous: 26 | Stop Codon: 0
Protein Length: 2543 | Molecular Weight (kDa): 296.919
UniProt ID(s): Q8IBR8
PDB ID(s): None
Isoelectric Point: 8.31
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000742 | EGF-like domain |
| InterPro | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| InterPro | IPR011641 | Tyrosine-protein kinase ephrin type A/B receptor-like |
| PFam | PF07699 | Tyrosine-protein kinase ephrin type A/B receptor-like |
| Superfamily | SSF57184 | Growth factor receptor cysteine-rich domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 17253978 | Plasmodium cysteine repeat modular proteins 1-4: complex proteins with rolesthroughout the malaria parasite life cycle. | Thompson J, Fernandez-Reyes D, ..., Waters AP | 10.1111/j.1462-5822.2006.00885.x |