PF3D7_0718400

Genome location: Pf3D7_07_v3:821,738..823,473(+)

Genome classification: Core

Function and Localization

Product Description: ribosomal protein S8, mitochondrial, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0022627	cytosolic small ribosomal subunit
Component	GO:0005763	mitochondrial small ribosomal subunit
Component	GO:0005739	mitochondrion
Function	GO:0003735	structural constituent of ribosome
Process	GO:0006412	translation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.03	0.98
Trophozoite	expressed	0.12	0.92
Schizont	expressed	0.08	0.94
Gametocyte	expressed	0.05	0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0718400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.153 | MFS: -2.673 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0616000)

Relative Growth Rate: 0.98 ± 0.09
Confidence: 6.15

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0616000)

Modification: Disrupted | RMgm-2132

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBR7

"Best" AlphaFill ligand hit: PAR (crestomycin, Local RMSD=0.46) with 4DR2 (Global RMSD=3.17)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100322

Most Similar Human Ortholog: P62244

TM-align score: 0.79 | RMSD: 1.75

Seq Identity: 0.23 | Length: 114 / 129

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000134419	ribosomal protein S15a

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 123

Non-coding: 118 | Synonymous: 4 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 129 | Molecular Weight (kDa): 14.803

UniProt ID(s): Q8IBR7

PDB ID(s): None

Isoelectric Point: 10.59

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000630	Ribosomal protein S8
InterPro	IPR035987	Ribosomal protein S8 superfamily
PFam	PF00410	Ribosomal protein S8
Superfamily	SSF56047	Ribosomal protein S8 superfamily