PF3D7_0718500

Genome location: Pf3D7_07_v3:824,069..826,448(+)

Genome classification: Core

Function and Localization

Product Description: prefoldin subunit 3, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005737	cytoplasm
Component	GO:0005844	polysome
Component	GO:0016272	prefoldin complex
Function	GO:0015631	tubulin binding
Function	GO:0051082	unfolded protein binding
Process	GO:0006458	'de novo' protein folding
Process	GO:0007017	microtubule-based process
Process	GO:0007021	tubulin complex assembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.17	0.91
Trophozoite	expressed	0.62	0.65
Schizont	expressed	0.25	0.84
Gametocyte	expressed	1.00	0.49

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0718500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.18 | MFS: -3.36 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0616100)

Relative Growth Rate: 0.75 ± 0.12
Confidence: 5.60

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0616100)

Modification: Disrupted | RMgm-2133

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBR6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102595

Most Similar Human Ortholog: P61758

TM-align score: 0.86 | RMSD: 1.78

Seq Identity: 0.33 | Length: 178 / 192

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000155959	VHL binding protein 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	12	7	8
disruptive	2	2	6	15
missense	2	2	6	12

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	20	6	15
disruptive	7	17	22	18
missense	3	12	20	12

PlasmoDB Total SNPs: 153

Non-coding: 149 | Synonymous: 4 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 192 | Molecular Weight (kDa): 22.642

UniProt ID(s): Q8IBR6

PDB ID(s): None

Isoelectric Point: 7

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR004127	Prefoldin alpha-like
InterPro	IPR016655	Prefoldin subunit 3
PFam	PF02996	Prefoldin alpha-like
Superfamily	SSF46579	N/A