PF3D7_0718600

Genome location: Pf3D7_07_v3:826,587..831,534(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	not expressed	0.15	0.91
Schizont	not expressed	0.29	0.84
Gametocyte	not expressed	0.13	0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0718600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.148 | #Insertions: 8

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZXK1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532950

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	37	25	63
disruptive	30	123	63	182
missense	16	107	55	151

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	71	45	62
disruptive	60	235	132	271
missense	30	198	108	187

PlasmoDB Total SNPs: 269

Non-coding: 178 | Synonymous: 52 | Nonsynonymous: 39 | Stop Codon: 0

Protein Information

Protein Length: 1114 | Molecular Weight (kDa): 131.881

UniProt ID(s): A0A143ZXK1

PDB ID(s): None

Isoelectric Point: 9.63

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A