PF3D7_0718700

Genome location: Pf3D7_07_v3:831,360..833,140(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 5

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.03	0.99
Trophozoite	expressed	0.26	0.84
Schizont	expressed	0.02	0.99
Gametocyte	possibly expressed	0.19	0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0718700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.982 | MFS: 0.741 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBR4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533066

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	15	13	18
disruptive	4	32	30	67
missense	4	32	29	64

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	31	15	27
disruptive	12	83	44	113
missense	10	73	38	88

PlasmoDB Total SNPs: 65

Non-coding: 34 | Synonymous: 25 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 457 | Molecular Weight (kDa): 53.858

UniProt ID(s): Q8IBR4

PDB ID(s): None

Isoelectric Point: 9.79

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF144091	N/A