PF3D7_0718800

Genome location: Pf3D7_07_v3:833,630..835,051(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.00	1.00
Trophozoite	possibly expressed	0.00	1.00
Schizont	possibly expressed	0.00	1.00
Gametocyte	expressed	0.07	0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0718800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.123 | MFS: -2.982 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0616400)

Relative Growth Rate: 1.03 ± 0.11
Confidence: 5.78

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0616400)

Modification: Disrupted | RMgm-2134

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4N6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_140582

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	8	4	17
disruptive	3	5	3	11
missense	3	4	2	9

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	16	6	18
disruptive	5	10	6	44
missense	4	7	6	27

PlasmoDB Total SNPs: 94

Non-coding: 85 | Synonymous: 6 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 273 | Molecular Weight (kDa): 31.283

UniProt ID(s): C0H4N6

PDB ID(s): None

Isoelectric Point: 9.6

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A