PF3D7_0719000

Genome location: Pf3D7_07_v3:837,682..839,204(+)

Genome classification: Core

Function and Localization

Product Description: translation machinery-associated protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0030674	protein-macromolecule adaptor activity
Process	GO:0070682	proteasome regulatory particle assembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.17	0.92
Trophozoite	not expressed	0.44	0.75
Schizont	not expressed	0.06	0.96
Gametocyte	not expressed	0.47	0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0719000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.128 | MFS: -3.107 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0616500)

Relative Growth Rate: 0.56 ± 0.31
Confidence: 3.76

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0616500)

Modification: Disrupted | RMgm-2135

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBR1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_157596

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 108

Non-coding: 94 | Synonymous: 12 | Nonsynonymous: 0 | Stop Codon: 2

Protein Information

Protein Length: 153 | Molecular Weight (kDa): 17.841

UniProt ID(s): Q8IBR1

PDB ID(s): None

Isoelectric Point: 4.93

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR038966	Translation machinery-associated protein 17
PFam	N/A	N/A
Superfamily	N/A	N/A