About Gene List

PF3D7_0719100

Genome location: Pf3D7_07_v3:838,686..840,277(-)

Genome classification: Core

Function and Localization

Product Description: ATP synthase F0 subunit a-like protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed 0.04 0.98
Trophozoite expressed 0.43 0.74
Schizont expressed 0.21 0.86
Gametocyte expressed 1.03 0.49

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0719100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.143 | MFS: -3.6 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBR0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_146141

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 9 7 16
disruptive 1 10 4 16
missense 1 9 4 14

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 16 13 10
disruptive 4 24 12 22
missense 1 20 9 18

PlasmoDB Total SNPs: 132

Non-coding: 124 | Synonymous: 5 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 179 | Molecular Weight (kDa): 21.33

UniProt ID(s): Q8IBR0

PDB ID(s): None

Isoelectric Point: 9.91

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21