Product Description: actin-related protein ARP6
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000812 | Swr1 complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0031491 | nucleosome binding |
| Function | GO:0005515 | protein binding |
| Process | GO:0043486 | histone exchange |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.32 | 0.84 |
| Trophozoite | expressed | 0.51 | 0.70 |
| Schizont | expressed | 0.09 | 0.94 |
| Gametocyte | expressed | 0.35 | 0.79 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0719300
Resistome Missense Mutations: V542I
Resistome Compounds with Missense Mutations: Desoxyepothilone B
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.368 | MFS: -2.587 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0616800)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0616800)
Modification: Disrupted | RMgm-2137
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IBQ9
"Best" AlphaFill ligand hit: TAD (beta-methylene-thiazole-4-carboxyamide-adenine dinucleotide, Local RMSD=0.08) with 3BUZ (Global RMSD=2.31)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103780
Most Similar Human Ortholog: Q9GZN1
TM-align score: 0.88 | RMSD: 2.83
Seq Identity: 0.26 | Length: 385 / 1032
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000075089 | actin related protein 6 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 36 | 24 | 62 |
| disruptive | 27 | 102 | 64 | 168 |
| missense | 16 | 62 | 49 | 138 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 13 | 78 | 41 | 60 |
| disruptive | 58 | 207 | 125 | 228 |
| missense | 27 | 150 | 108 | 156 |
PlasmoDB Total SNPs: 210
Non-coding: 132 | Synonymous: 53 | Nonsynonymous: 25 | Stop Codon: 0
Protein Length: 1032 | Molecular Weight (kDa): 121.129
UniProt ID(s): Q8IBQ9
PDB ID(s): None
Isoelectric Point: 7.02
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004000 | Actin family |
| InterPro | IPR030054 | Actin-related protein 6 |
| InterPro | IPR043129 | ATPase, nucleotide binding domain |
| PFam | PF00022 | Actin family |
| Superfamily | SSF53067 | ATPase, nucleotide binding domain |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 32552779 | Actin-related protein Arp4 regulates euchromatic gene expression and developmentthrough H2A.Z deposition in blood-stage Plasmodium falciparum. | Liu H, Cui XY, ..., Xia H | 10.1186/s13071-020-04139-6 |
| 37047144 | The Arabidopsis Deubiquitylase OTU5 Suppresses Flowering by HistoneModification-Mediated Activation of the Major Flowering Repressors FLC, MAF4, andMAF5 | Radjacommare R, Lin SY, ..., Fu H | 10.3390/ijms24076176 |
| 31350403 | Arabidopsis SWR1-associated protein methyl-CpG-binding domain 9 is required for histone H2A.Z deposition | Potok ME, Wang Y, ..., Jacobsen SE | 10.1038/s41467-019-11291-w |
| 36897355 | Actin-related protein 6 facilitates proneural protein-induced gene activation for rapid neural differentiation | Hsiao YL, Chen HW, ..., Pi H | 10.1242/dev.201034 |
| 38319641 | Actin-related protein ARP4 and ARP6 antagonistically regulate DNA demethylase ROS1 in plants | Nie WF, Mao Y, Xing E, Liu R | 10.1093/plphys/kiae058 |
| 37120038 | PIFs interact with SWI2/SNF2-related 1 complex subunit 6 to regulate H2A.Z deposition and photomorphogenesis in Arabidopsis | Chen H, Wang W, ..., Mao Z | 10.1016/j.jgg.2023.04.008 |
| 32353561 | The complexity and diversity of the actin cytoskeleton of trypanosomatids | Vizcaino-Castillo A, Osorio-Mendez JF, ..., Cevallos AM | 10.1016/j.molbiopara.2020.111278 |