PF3D7_0719400

Genome location: Pf3D7_07_v3:848,223..853,891(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.14	0.93
Trophozoite	expressed	0.80	0.59
Schizont	expressed	0.95	0.52
Gametocyte	expressed	1.68	0.26

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0719400

Resistome Missense Mutations: H836N

Resistome Compounds with Missense Mutations: AN13762, AN13956

Resistome # Samples with Disruptive Mutations: 7 (7 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.574 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBQ8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533483

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	14	72	27	67
disruptive	132	181	104	260
missense	38	108	88	203

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	19	125	49	90
disruptive	214	371	190	378
missense	63	243	146	269

PlasmoDB Total SNPs: 266

Non-coding: 37 | Synonymous: 130 | Nonsynonymous: 99 | Stop Codon: 0

Protein Information

Protein Length: 1731 | Molecular Weight (kDa): 205.977

UniProt ID(s): Q8IBQ8

PDB ID(s): None

Isoelectric Point: 9.54

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A