Product Description: cell division control protein CDC50A
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005794 | Golgi apparatus |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0005886 | plasma membrane |
| Process | GO:0071976 | cell gliding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | 0.06 | 0.97 |
| Trophozoite | expressed | 0.32 | 0.80 |
| Schizont | expressed | 0.50 | 0.69 |
| Gametocyte | expressed | 0.48 | 0.74 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0719500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.184 | MFS: -2.777 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_0619700)
Modification: Disrupted | RMgm-4796
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A143ZVJ8
"Best" AlphaFill ligand hit: P5S (phosphatidyl serine, Local RMSD=0.53) with 6LKN (Global RMSD=4.09)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100927
Most Similar Human Ortholog: E5RG19
TM-align score: 0.80 | RMSD: 1.77
Seq Identity: 0.39 | Length: 72 / 471
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000112697 | transmembrane protein 30A |
| ENSG00000182107 | transmembrane protein 30B |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 13 | 7 | 17 |
| disruptive | 7 | 16 | 13 | 44 |
| missense | 5 | 15 | 12 | 40 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 27 | 16 | 35 |
| disruptive | 14 | 50 | 43 | 83 |
| missense | 6 | 39 | 36 | 66 |
PlasmoDB Total SNPs: 183
Non-coding: 160 | Synonymous: 21 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 471 | Molecular Weight (kDa): 55.314
UniProt ID(s): A0A143ZVJ8
PDB ID(s): None
Isoelectric Point: 9.05
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005045 | CDC50/LEM3 family |
| PFam | PF03381 | CDC50/LEM3 family |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 30146157 | ISP1-Anchored Polarization of GCbeta/CDC50A Complex Initiates Malaria OokineteGliding Motility. | Gao H, Yang Z, ..., Yuan J | 10.1016/j.cub.2018.06.069 |
| 37093479 | Expression in Saccharomyces cerevisiae and Purification of a Human PhospholipidFlippase | Dieudonne T, Jaxel C, ..., Montigny C | 10.1007/978-1-0716-3147-8_13 |
| 35862778 | CDC50 Orthologues in Plasmodium falciparum Have Distinct Roles in MerozoiteEgress and Trophozoite Maturation | Patel A, Nofal SD, Blackman MJ, Baker DA | 10.1128/mbio.01635-22 |