Product Description: 60S ribosomal protein L11a, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022625 | cytosolic large ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0000027 | ribosomal large subunit assembly |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 1.26 | 0.51 |
| Trophozoite | no data | 1.79 | 0.27 |
| Schizont | no data | 0.23 | 0.86 |
| Gametocyte | no data | 0.56 | 0.70 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0719600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.847 | MFS: -2.407 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IBQ6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100325
Most Similar Human Ortholog: Q5VVC8
TM-align score: 0.98 | RMSD: 0.31
Seq Identity: 0.70 | Length: 165 / 173
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000142676 | ribosomal protein L11 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 1 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 1 | 0 | 1 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 106
Non-coding: 101 | Synonymous: 3 | Nonsynonymous: 0 | Stop Codon: 2
Protein Length: 173 | Molecular Weight (kDa): 20.228
UniProt ID(s): Q8IBQ6
PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD
Isoelectric Point: 10.76
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002132 | Ribosomal protein L5 |
| InterPro | IPR022803 | Ribosomal protein L5 domain superfamily |
| InterPro | IPR031309 | Ribosomal protein L5, C-terminal |
| InterPro | IPR031310 | Ribosomal protein L5, N-terminal |
| PFam | PF00281 | Ribosomal protein L5, N-terminal |
| PFam | PF00673 | Ribosomal protein L5, C-terminal |
| Superfamily | SSF55282 | Ribosomal protein L5 domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 24913268 | Cryo-E M structure of the Plasmodium falciparum 80 S ribosome bound to theanti-protozoan drug emetine | Wong W, Bai XC, ..., Scheres SH | 10.7554/eLife.03080 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |