PF3D7_0719800

Genome location: Pf3D7_07_v3:862,922..865,648(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.15	0.93
Trophozoite	expressed	0.32	0.80
Schizont	expressed	0.16	0.89
Gametocyte	expressed	0.24	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0719800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.243 | MFS: -3.54 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0617300)

Relative Growth Rate: 0.09 ± 0.11
Confidence: 5.86

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBQ4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139451

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	16	11	22
disruptive	5	20	11	24
missense	3	17	11	23

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	42	11	23
disruptive	15	37	25	66
missense	9	30	18	46

PlasmoDB Total SNPs: 92

Non-coding: 72 | Synonymous: 14 | Nonsynonymous: 4 | Stop Codon: 2

Protein Information

Protein Length: 453 | Molecular Weight (kDa): 54.96

UniProt ID(s): Q8IBQ4

PDB ID(s): None

Isoelectric Point: 10.37

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
30212465	Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites.	Boucher MJ, Ghosh S, ..., Yeh E	10.1371/journal.pbio.2005895