PF3D7_0719900

Genome location: Pf3D7_07_v3:865,738..876,273(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005802	trans-Golgi network

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.87	0.63
Trophozoite	possibly expressed	1.52	0.33
Schizont	expressed	0.95	0.55
Gametocyte	possibly expressed	1.29	0.38

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0719900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 4 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.165 | MFS: -2.803 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533028

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	49	160	84	182
disruptive	325	535	273	594
missense	132	315	207	424

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	82	262	135	185
disruptive	485	890	382	753
missense	189	588	295	491

PlasmoDB Total SNPs: 498

Non-coding: 27 | Synonymous: 241 | Nonsynonymous: 230 | Stop Codon: 0

Protein Information

Protein Length: 3401 | Molecular Weight (kDa): 402.702

UniProt ID(s): Q8IBQ3

PDB ID(s): None

Isoelectric Point: 8.43

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR013935	TRAPP II complex, Trs120
PFam	N/A	N/A
Superfamily	N/A	N/A