PF3D7_0720100 (ESF2)

Genome location: Pf3D7_07_v3:877,733..879,225(-)

Genome classification: Core

Function and Localization

Product Description: pre-rRNA-processing protein ESF2, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005730	nucleolus
Function	GO:0003723	RNA binding
Process	GO:0000480	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Process	GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Process	GO:0000472	endonucleolytic cleavage to generate mature 5'-end of
Process	GO:0034462

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.65	0.70
Trophozoite	expressed	0.52	0.71
Schizont	expressed	0.16	0.90
Gametocyte	expressed	0.43	0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0720100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.199 | MFS: -2.807 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBQ1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102746

Most Similar Human Ortholog: Q9ULW3

TM-align score: 0.43 | RMSD: 3.75

Seq Identity: 0.23 | Length: 133 / 255

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000146109	activator of basal transcription 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	11	11	8
disruptive	2	33	23	46
missense	1	31	23	42

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	23	8	19
disruptive	5	80	37	63
missense	4	70	36	43

PlasmoDB Total SNPs: 64

Non-coding: 54 | Synonymous: 3 | Nonsynonymous: 6 | Stop Codon: 1

Protein Information

Protein Length: 255 | Molecular Weight (kDa): 30.481

UniProt ID(s): Q8IBQ1

PDB ID(s): None

Isoelectric Point: 10.27

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR035979	RNA-binding domain superfamily
InterPro	IPR039119	ABT1/Esf2
PFam	N/A	N/A
Superfamily	SSF54928	RNA-binding domain superfamily