Product Description: apoptosis-inducing factor, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 1.18.1.2 (Ferredoxin--NADP(+) reductase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Function | GO:0015036 | disulfide oxidoreductase activity |
| Function | GO:0009055 | electron transfer activity |
| Process | GO:0055114 | oxidation-reduction process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.16 | 0.92 |
| Trophozoite | expressed | 0.61 | 0.66 |
| Schizont | expressed | 0.13 | 0.92 |
| Gametocyte | possibly expressed | 0.29 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0720400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.996 | MFS: -2.908 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_0617900)
Modification: Other | RMgm-426
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IBP8
"Best" AlphaFill ligand hit: PAP (3'-phosphate-adenosine-5'-diphosphate, Local RMSD=0.03) with 8A56 (Global RMSD=1.94)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 1.18.1.2 | ferredoxin-NADP+ reductase | BRENDA SOAP query unsuccessful |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100481
Most Similar Human Ortholog: C9K029
TM-align score: 0.86 | RMSD: 3.24
Seq Identity: 0.28 | Length: 559 / 642
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000183773 | apoptosis inducing factor mitochondria associated 3 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 30 | 11 | 24 |
| disruptive | 6 | 24 | 19 | 58 |
| missense | 5 | 24 | 19 | 50 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 15 | 47 | 20 | 33 |
| disruptive | 17 | 66 | 33 | 122 |
| missense | 9 | 58 | 24 | 86 |
PlasmoDB Total SNPs: 80
Non-coding: 57 | Synonymous: 19 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 642 | Molecular Weight (kDa): 72.722
UniProt ID(s): Q8IBP8
PDB ID(s): None
Isoelectric Point: 8.93
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR016156 | FAD/NAD-linked reductase, dimerisation domain superfamily |
| InterPro | IPR017941 | Rieske [2Fe-2S] iron-sulphur domain |
| InterPro | IPR023753 | FAD/NAD(P)-binding domain |
| InterPro | IPR036188 | FAD/NAD(P)-binding domain superfamily |
| InterPro | IPR036922 | Rieske [2Fe-2S] iron-sulphur domain superfamily |
| PFam | PF00355 | Rieske [2Fe-2S] iron-sulphur domain |
| PFam | PF07992 | FAD/NAD(P)-binding domain |
| Superfamily | SSF50022 | Rieske [2Fe-2S] iron-sulphur domain superfamily |
| Superfamily | SSF51905 | FAD/NAD(P)-binding domain superfamily |
| Superfamily | SSF55424 | FAD/NAD-linked reductase, dimerisation domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 38397565 | Rapid Acidification and Off-Flavor Reduction of Pea Protein by Fermentation withLactic Acid Bacteria and Yeasts | Zipori D, Hollmann J, ..., Schmidt H | 10.3390/foods13040588 |