PF3D7_0720500

Genome location: Pf3D7_07_v3:885,897..888,194(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.01	1.00
Trophozoite	expressed	0.07	0.95
Schizont	expressed	0.02	0.99
Gametocyte	expressed	0.10	0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0720500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.169 | MFS: -3.381 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0618000)

Relative Growth Rate: 0.32 ± 0.19
Confidence: 4.68

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0618000)

Modification: Disrupted | RMgm-4219

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H4N9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533516

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 122

Non-coding: 111 | Synonymous: 10 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 134 | Molecular Weight (kDa): 16.059

UniProt ID(s): C0H4N9

PDB ID(s): None

Isoelectric Point: 9.67

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A