Product Description: phosphoinositide-binding protein PX1
SignalP Peptide: N/A
# Transmembrane Domains: 4
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005769 | early endosome |
| Component | GO:0020020 | food vacuole |
| Component | GO:0016020 | membrane |
| Component | GO:0031982 | vesicle |
| Function | GO:0035091 | phosphatidylinositol binding |
| Function | GO:0032266 | phosphatidylinositol-3-phosphate binding |
| Process | GO:0006886 | intracellular protein transport |
| Process | GO:0009410 | response to xenobiotic stimulus |
| Process | GO:1990126 | retrograde transport, endosome to plasma membrane |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.41 | 0.42 |
| Trophozoite | expressed | 1.02 | 0.49 |
| Schizont | expressed | 2.29 | 0.15 |
| Gametocyte | expressed | 1.70 | 0.26 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0720700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.65 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IBP4
"Best" AlphaFill ligand hit: PIB (d-myo-phosphatidylinositol 3-phosphated (+)-sn-1,2-di-o-butanoylglyceryl,3-o-phospho, Local RMSD=3.06) with 2RAK (Global RMSD=3.92)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 29 | 101 | 64 | 126 |
| disruptive | 129 | 332 | 165 | 398 |
| missense | 58 | 213 | 126 | 286 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 43 | 186 | 89 | 133 |
| disruptive | 221 | 609 | 290 | 587 |
| missense | 87 | 411 | 204 | 379 |
PlasmoDB Total SNPs: 545
Non-coding: 283 | Synonymous: 148 | Nonsynonymous: 114 | Stop Codon: 0
Protein Length: 2166 | Molecular Weight (kDa): 258.426
UniProt ID(s): Q8IBP4
PDB ID(s): None
Isoelectric Point: 6.71
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001683 | Phox homologous domain |
| InterPro | IPR036871 | PX domain superfamily |
| InterPro | IPR037831 | SNX17/27/31 |
| PFam | PF00787 | Phox homologous domain |
| Superfamily | SSF64268 | PX domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 35038916 | A Phosphoinositide-Binding Protein Acts in the Trafficking Pathway of Hemoglobinin the Malaria Parasite Plasmodium falciparum. | Mukherjee A, Crochetiere ME, ..., Richard D | 10.1128/mbio.03239-21 |