About Gene List

PF3D7_0720800

Genome location: Pf3D7_07_v3:899,525..901,353(+)

Genome classification: Core

Function and Localization

Product Description: Ham1-like protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 3.6.1.66 (XTP/dITP diphosphatase);3.6.1.9 (Nucleotide diphosphatase)

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005737 cytoplasm
Function GO:0047429 nucleoside-triphosphate diphosphatase activity
Process GO:0009143 nucleoside triphosphate catabolic process

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed 0.07 0.96
Trophozoite expressed 0.56 0.67
Schizont expressed 0.10 0.93
Gametocyte expressed 0.55 0.68

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0720800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.139 | MFS: -2.831 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0618300)

Modification: Disrupted | RMgm-4582

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IBP3

"Best" AlphaFill ligand hit: POP (pyrophosphate 2-, Local RMSD=0.67) with 2J4E (Global RMSD=3.90)

BRENDA EC Inhibitors:

EC # Name EC Inhibitors
3.6.1.66 XTP/dITP diphosphatase No BRENDA inhibitors
3.6.1.9 nucleotide diphosphatase ATPADPAMPGDPCTPUTPSDSUMPGSHGMPITPNaF...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100769

Most Similar Human Ortholog: Q9BY32

TM-align score: 0.89 | RMSD: 1.39

Seq Identity: 0.34 | Length: 182 / 198

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000125877 inosine triphosphatase

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 5 6 11
disruptive 4 8 6 39
missense 4 8 6 30

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 1 15 10 11
disruptive 5 26 29 58
missense 5 20 19 42

PlasmoDB Total SNPs: 138

Non-coding: 125 | Synonymous: 10 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 198 | Molecular Weight (kDa): 23.08

UniProt ID(s): Q8IBP3

PDB ID(s): None

Isoelectric Point: 6.87

Protein Domain Annotations:

Source Family ID Description
InterPro IPR002637 Ham1-like protein
InterPro IPR027502 Inosine triphosphate pyrophosphatase
InterPro IPR029001 Inosine triphosphate pyrophosphatase-like
PFam PF01725 Ham1-like protein
Superfamily SSF52972 Inosine triphosphate pyrophosphatase-like

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095